Toxicity

ERDC cell screening and surrogate bioassays are used to assess the potential toxicity of nanomaterials to humans. A broad range of terrestrial and aquatic bioassay tests are used to determine ecotoxicity of nanomaterials. These methods are used to generate high quality toxicological data tailored to specific nanomaterials and nanotechnology. Toxicity assessment capabilities provide standardized and customized methods to predict effects in complex environmental systems.

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ERDC uses mixed alveolar cell and macrophage cultures for in vitro screening of nanoparticle toxicity

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Exposure, uptake, and ecotoxicity of nanoparticles are determined using a wide range of invertebrate and vertebrate bioassays

Capabilities

  • Brunauer, Emmet and
    Teller Surface Area Analysis
  • CytoViva Microscope
    Hyperspectral Imaging
  • Disk centrifuge particle counting
  • Diverse suite of acute and
    chronic toxicological bioassays
    for whole organisms (freshwater, marine, sediment)
  • Electrophoretic mobility and point
    of zero charge determination
  • High resolution UV-vis and NIR photospectrometry determination
    of concentration and aggregation
  • Noldus DanioVision
    Behavioral analysis

Education

  • M.S., Mississippi College, MS, 2009, Environmental Science
  • B.S., Mississippi State University, MS, 2005, Biological Science

Research Projects

  • Biological uptake of nano particles in terrestrial and aquatic species
  • Bioavailability of IMX-101 to terrestrial biota
  • Formation and fate of Lead metal rich granules in terrestrial invertebrates
  • Fate and effects of Depleted Uranium in terrestrial systems

Jessica Coleman

Research Biologist

Publications

Education

  • Ph.D., Pennsylvania State University, MS Hershey College of Medicine,
    Hershey, PA, 2009, Integrative Biosciences
  • B.S., Rochester Institute of Technology, Rochester, NY, 2000, Biotechnology

Research Projects

  • Immunotoxicology for Wide Area Decontamination Project
  • Immunotoxicology for Post-Combustion Nanomaterials
  • Paddlefish Bio-inspiration Project

Keri Donohue

Immunologist

Publications

Education

  • M.S., Mississippi State University, Mississippi State, MS, 2009,
    Veterinary Medical Science
  • B.S., Mississippi State University, Mississippi State, MS, 2006, Biology

Research Projects

  • Bioavailability and Degradation Pathways for 2,4 Dinitroanisole
  • Nanotechnology Development: Integrating Design with Environmental
    Sustainability Objectives

Ashley Harmon

Research Biologist

Publications

Education

  • M.S., Texas A&M University, College Station, TX, 2012, Wildlife Science
  • B.S., Mississippi College, Clinton, MS, 2004, Biology

Research Projects

  • Daphnia population sensitivity to DNAN
  • Dosimetry studies of varying sizes of Ag nanoparticles
  • Nano Copper aquatic toxicity to freshwater cladocerans
  • Oxidative stress of fathead minnows exposed to Ag nanoparticles

Jenny Laird

Research Biologist